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Nucleic Acids 7 , 278287 (2017)

The most common types of ROS damage in organ preservation stem from 1) the breakdown of purines during hypoxia (e.g., in static cold storage) and/or 2) excessive superoxide production from electron leakage from the electron transport chain during reperfusion (i.e., the re-introduction of blood flow), resulting in excessive hydrogen peroxide production, glutathione (GSH) depletion, and mitochondrial dysfunction

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Functional medicine providers use glutathione infusion therapies to lessen oxidative stress, which can be the root cause of chronic inflammation

Immunoreactivity in cKO brains ( n = 3 per group) was significantly reduced compared with the littermate controls at all locations except for around 3 m from vessel walls, as expected (Fig