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The most important of these is the Nuclear Factor-Kappa B (NF-B) cascade, as it directly activates and transcribes most gene targets that regulate and amplify the inflammatory response ( i.e

169 Novel types of programmed cell death Cell death is crucial for the development and maintenance of homeostasis in organisms and can be categorized into accidental cell death and regulated cell death (RCD), depending on its controlled nature

However, some have not been sufficiently tested with humans at this point

[DOI] [PubMed] [Google Scholar] 152.Kaneda Y, Nakajima T, Nishikawa T, Yamamoto S, Ikegami H, Suzuki N, Nakamura H, Morishita R, Kotani H

10.1038/nrm.2017.95 58