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Conversely, it is estimated that 80% of the men with varicocele are fertile, making the association between varicocele and decreased semen quality controversial in fertile males (7-10)

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( Reference Madan, Batra and Gupta 75 ) found that a combination of lifestyle modifications, ursodeoxycholic acid and vitamin E provided better effects than when lifestyle modifications alone was used in normalising the ALT levels

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Recent studies have underscored the role of the TET family of enzymes, a new class of epigenetic regulators that catalyze the conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), thereby facilitating DNA demethylation and impacting gene expression (Babar et al