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Professor Ngs research contributions to AOD-9604 development include: Synthesis and characterization of the modified C-terminal growth hormone fragment with enhanced stability Design of the tyrosine N-terminal modification to improve peptide stability and half-life Preclinical studies demonstrating lipolytic effects in obese animal models Advancement of the peptide through multiple phases of clinical development Investigation of mechanisms underlying beta-3-adrenergic receptor modulation His work established the foundation for understanding peptide-based approaches to metabolic regulation, though clinical translation ultimately proved unsuccessful

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It identifies the subset of patients who truly benefit from supplementation

Shigeki Watanabe Reference: Imoto et al., 2022, Neuron

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These stacks often include peptides like sermorelin or CJC-1295 alongside the NNMT inhibitor