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To partially compensate for this, patients are often given high systemic doses, which may increase brain exposure but also lead to significant off-target toxicity

[6] Premarketing surveillance of parenteral arginine formulations identified nausea, vomiting, headache, flushing, numbness, and local venous irritation in approximately three per cent of infusions

Paganoni S, Cudkowicz M, Berry JD

The localization of FUNDC1 at ER-mitochondria contact sites (MAMs) and its role in integrating mitophagy, mitochondrial adaptation, and ER stress responses exemplify how spatial organization determines functional proteostasis outcomes

Reports on glioblastoma, one of the most aggressive types of cancer, describe a positive correlation between tumor clearance and VEGF-C-mediated meningeal lymphangiogenesis (203)

doi: 10.1007/s00011-011-0392-8