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Because GTK is (1) particularly prominent in vitro as a -lyase with toxic cysteine S -conjugates such as TFEC (Table 1), (2) the enzyme is present in rat and human kidney proximal tubules (e.g., Jones et al., 1988, Cooper et al., 1993, Kim et al., 1997), and (3) the proximal tubules are especially prone to damage from toxic halogenated cysteine S -conjugates

In contrast to the expression of MDA and GSH in the circulation, we detected significantly lower MDA and higher GSH, TEAC, and GSH-Px activity in HCC tissue when compared to adjacent normal tissue

science 287 (5460):2013-2017 Hata AN, Breyer RM (2004) Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation

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It's also well documented that elevated homocysteine levels increase risk for blood clots

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