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Clinical research has shown that metabolites or peptides produced by the gut microbiome can act as ligands, which interact with host receptors and trigger downstream signaling
An imbalance of free radicals and antioxidants can cause oxidative stress

Thus, the main role of MPO is to maintain the immune system and antimicrobial protection against various toxins and pathogens

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Changes in physicochemical and gut microbiota fermentation property induced by acetylation of polysaccharides from Cyperus esculentus

Furthermore, oxidative stress impairs nitric oxide (NO) bioavailability, reducing vasodilation and increasing vascular stiffness [188]
