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Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites

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Frigeni M, Iacobazzi F, Yin X, et al

These changes are tightly linked to mechanisms including chronic low-grade inflammation, progressive insulin resistance, mitochondrial dysfunction, and alterations in adipocyte structure that become more pronounced with menopause and the gradual loss of muscle mass (Ross et al., 2002)

371,372 Oxidative stress and inflammation induced by elevated ROS are involved in many diabetic complications