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However, this consensus is not universally true, as some -3 epoxy-PUFA-metabolites promote allergic responses by attenuating mast cell activation while an -6 PUFA-metabolite (lipoxin A 4 ) has been shown to be more pro-resolving (Shimanaka et al., 2017)

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Others may be used in clinical settings under medical supervision, depending on availability, regulations, and patient needs

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