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In the circulation, two of the IGFBPs, IGFBP-3 and IGFBP-5, are bound to a further large glycoprotein, the acid-labile subunit, that is present in excess [11]

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So we can excrete HUGE amounts of B12 in a short time if it is extraneous to the amount we currently need

Additionally, antibody-based biomarkers hold promise for predicting treatment outcomes and identifying individuals at increased risk of disease relapse, thereby informing clinical decision-making, and improving patient outcomes

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These include oxidative damage, epigenetic remodeling, endocrine disruption, chronic inflammation, changes in the tumor microenvironment, and the emergence of distinct mutational patterns [12]