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Description
Benign conditions are by far the most likely explanation

In the presence of excess activated G q and G , PLC 3 activity is stimulated approximately 19-fold over what either G q or G can induce, which appears to depend on the very low basal activity of PLC 3 (Philip et al., 2010)
Mhlroth, A., Winge, P., El Assimi, A., Jouhet, J., Marchal, E., Hohmann-Marriott, M

The exothermic reaction triggered by rubbing and water helps to remove impurities from your pores

the physiological impact is less central than MC3/MC4 but can contribute to overall systemic effects 4

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