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Description
Some authors suggest that impairments within the endogenous opioid system, such as those proposed here, may, over time, lead to the hyperactivation of pain pathways, and, therefore, transform normal stimuli into painful or heightened responses toward typical pain stimuli (allodynia and hyperalgesia, respectively) [137]
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This is not subtle modulation
Some do it several times a week, and others less frequently
doi: 10.1002/eji.202350901 20 CeppelliniRGarottaGMalavasiFTruccoM
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