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Under specific stress conditionsincluding high local concentrations, altered pH, oxidative stress, or exposure to metal ions-syn can shift from its disordered or helical conformations to -sheet-rich assemblies, initiating fibrillization [1, 86, 280]

[3] This was later improved using guanidinium thiocyanate or guanidinium hydrochloride as the chaotropic agent

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The type of melanonychia varies with the causative drug

This helps to form a strong and stable network that supports the cell membrane