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There were significant differences in PDW in the MTHFR 677 CC/CT genotype group and in creatinine in the MTHFR 677 TT genotype group between the enalapril and enalapril-folic acid treatment groups

Under neuroinflammatory conditions, dysfunctional mitochondria release ROS and damage-associated molecular patterns (DAMPs) (53), activating microglia and astrocytes, and triggering the release of pro-inflammatory cytokines and chemokines (54), thereby exacerbating the damage

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Their excellent biocompatibility and low immunogenicity improve circulation time and in vivo stability [113]