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They are not intended to reach the systemic circulation, but rather exert their action through interaction with resident members of the microbiota and/or by modulating complex host-microbiota interactions

Stress Science: Neuroendocrinology (Academic, 2010)

A therapeutic recreation program has been demonstrated to enhance social skills, evidenced by improvements in social reciprocity and participation

doi: 10.3389/fgene.2015.00135 43

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At therapeutic doses most paracetamol undergoes glucuronidation and sulfation, but a fraction is bioactivated by cytochrome P450 to Nacetylpbenzoquinone imine (NAPQI), which is detoxified by glutathione