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DSIP has been shown to influence neurotransmitter levels, including serotonin (5-HT), glutamate, dopamine, and melatonin, which are crucial for sleep regulation 2

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Overuse, incorrect depth, or poor technique can lead to more pronounced localized swelling, which is typically managed with proper aftercare and professional supervision

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The study by Hendren et al

Several patents are available for drug delivery via the nasal route to either directly target the CNS, or by systemic transport of the drugs by the nasal route to target the CNS