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Low dietary intake of creatine has been correlated with increased risk of depression, and altered brain creatine metabolism has been identified as a potential factor in depression

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The Innovation Medicine 3 :100160

EMBO J 22:48154825

In addition, circadian rhythm disruption can lead to the upregulation of Per1GSK3/catenin signaling in mandibular condylar chondrocytes, resulting in increased expression of cartilage matrixdegrading enzymes and the development of temporomandibular joint OA [145]