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Patients with autoimmune DED often experience damage to ocular surface tissues such as the cornea, conjunctival goblet cells, and lacrimal glands

Ketone body utilization occurs in extrahepatic tissues , such as: Brain (during prolonged fasting) Heart muscle Skeletal muscle Renal cortex Ketone bodies are converted back into acetyl-CoA , which enters the TCA cycle to generate ATP

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Pandemics such as COVID-19 exacerbate stress, disrupting HPA function and increasing mental health issues, including post-traumatic stress disorder, depression and anxiety

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Rat hair metabolomics analysis reveals perturbations of unsaturated fatty acid biosynthesis, phenylalanine, and arachidonic acid metabolism pathways are associated with amyloid--induced cognitive deficits