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These benefits are mediated through the downregulation of the high mobility group box 1 (HMGB1)/toll-like receptor 4 (TLR4)/NF-B inflammatory pathway, activation of PI3K/protein kinase B (Akt) pro-survival signaling, and inhibition of excessive neutrophil infiltration via ALX/FPR2 receptors in the spleen and left ventricle, limiting uncontrolled inflammation [106]

[DOI] [PubMed] [Google Scholar] 124.Thaut M, Kenyon G, Hurt C, McIntosh G, Hoemberg V

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2 ) oxidation of amino acid side chains, one example of which is 4-oxo-histidine

To further examine the impact of protein synthesis we examined the impact of decreasing the rate of protein synthesis by using a strain that expresses the constitutively active allele of AMPK CA-AAK-2 which leads to similar phenotypes to those observed during dietary restriction (24)