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10.1016/j.exger.2018.12.017 Exper

It has been shown that reprogramming HCC cells with nuclear factors such as HNF1A, HNF4A and FOXA3, can convert these cancerous cells to hepatocyte-like cells ( When using primary human hepatocytes to assess DILI, it is common to pool cells from multiple donors due to the limited number of viable hepatocytes that can be isolated from each individual (Figure 6), and importantly, we identified based on the incidence and the severity that donepezil and sitaxentan are categorized as less-DILI concern and most-DILI concern compounds, respectively (Figure 8)
Janvier, S., Cheyns, K., Canfyn, M., Goscinny, S., De Spiegeleer, B., Vanhee, C., & Deconinck, E

58 This information is an important component to establish a diagnosis of IC/BPS, provides a baseline against which treatments can be evaluated, and is used to determine the appropriate level of entry into the treatment algorithm
Health, 11: 83-90

Laboratory studies explore optimal administration regimens for different research objectives, including acute versus chronic senescent cell elimination and the effects of repeated administrations on tissue function and aging markers