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Glutamine has historically been one of the most intensely investigated nutrients in cancer metabolism and is involved in various aspects of biosynthesis and bioenergetics, including NEAA production, epigenetic gene control, adaptation to hypoxic conditions, ATP synthesis, cell signaling, and tumorigenesis
2010;10, article 51 doi: 10.1186/1472-6882-10-51
Cisplatin-induced ototoxicity (CIO) is characterised by hair cell death through the formation of DNA adducts, mitochondrial dysfunction, oxidative stress and inflammation, ultimately leading to apoptosis, necrotic apoptosis, pyroptosis, or ferroptosis (Tan and Vlajkovic, 2023)
10.1152/ajpgi.90227.2008 86 EwaschukJ.EndersbyR.ThielD.DiazH.BackerJ.MaM.et al
doi: 10.1111/mmi.14870 32 HillionM.AntelmannH
Regarding radiological analysis, 45% of the group that received NAC improved the radiological image compared to 30.8% of the control group, with no significant adverse effects
