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An institutional review board (IRB) in the USA (Pearl IRB) considered this study to be exempt according to FDA 21 CFR 56.104 and 45CFR46.104(b)(2):(2)

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In addition to altering the biosynthesis of dopamine, some cytokines can regulate dopamine storage

Phase 3 transports the compound out of the body through the bile or urine

It can have both short-term and long-term effects on the body