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Histamine and NGF, in turn, promote release of CGRP by neurons, creating a bidirectional positive feedback loop between nerve fibers and immune cells

The specific mechanism may be by activating VEGF-A / VEGFR1 -mediated AKT and p38/MAPK signaling pathways to upregulate downstream eNOS expression, which may increase the NO product synthesis thus promote angiogenesis of gastric mucosa, and also interact with ER stress

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Lin and Hsu 2018

Compared with Retatrutide, it remains more selective because it does not include glucagon receptor agonism
