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When pancreatic enzyme is activated, pancreatic acinars are damaged and a large amount of pancreatic enzymes released to cause pancreatic tissues into self-digest, edema, and bleeding, then leading to local inflammatory reactions (1)

In tissue engineering and regenerative medicine, LNPs enable spatially controlled payload release in both 2D and 3D tissue models, addressing challenges in programable cell-to-cell signal transport [366]