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While MSM is generally considered safe, it may interact with certain medications or cause side effects in some people

Such a trial to study treatment of hyperpigmentation with glutathione must also study long-term effects of single treatment, maintenance of effect over time and value of at least one repeat treatment

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Vitamin E [5] Vitamin B2 [6] -Glutathione level is significantly related to Vitamin E level, and supplementation with Vitamin E (100 IU/day) significantly increases Glutathione and lowers lipid per-oxidation and HbA1c concentrations in the erythrocytes of type 1 diabetic patients