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Peptide permeability depends on molecular size, with smaller peptides showing better absorption due to reduced resistance from the skin barrier [79]

doi:10.1002/9780470123058.ch3

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however, the injection of crocin can improve the physiological state of cells in the hippocampus and the overall memory of mice (Lin et al., 2017)

Tolerance and response: a provider adjusts based on how a patient actually responds over time, which no static number can anticipate