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Structurally, the BBB is highly lipophilic and composed of cerebrovascular endothelial cells, astrocytes, pericytes, neuronal cells, immune cells, microglial cells, glial cells, smooth muscle cells, and a basement membrane (Fig

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However, no controlled human trial has compared oral versus injectable AOD-9604 at equivalent systemic doses

2 Similarly, people who have undergone gastrointestinal procedures, including weight loss surgery, may be at increased risk of vitamin B12 deficiency

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