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Since the ER lacks glutathione reductase the oxidized glutathione (GSSG) must be transported to the cytosol for reduction

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Through co-immunoprecipitation (CO-IP) experiments, we discovered that FOXO4-DRI prevents the binding of FOXO4 to P53, facilitating the phosphorylated P53 nuclear exclusion, which subsequently trigger BAX and cleaved caspase-3, leading to the apoptosis of senescent cells

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