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NAC deacetylates under the action of N-deacetylase to enhance intracellular Cys, thereby increasing the endogenous synthesis of GSH

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This increases absorption while allowing for much larger doses than can be taken orally

doi: 10.1016/j.neurobiolaging.2012.11.023

In case of simultaneous administration of glutathione and the chemotherapeutic agent, the intravenous infusion of TAD should be performed 15-30 minutes before the start of chemotherapy