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There have also been concerns raised in the scientific literature regarding cardiovascular safety

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A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy

Specifically, the Phenol red thread test, a conventional method for assessing tear production, indicated reduced readings, implying decreased tear output

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Central venous access is preferred for cumulative dosing above 20 g to avoid phlebitis, and continuous electrocardiography, non-invasive blood-pressure, and pulse-oximetry are minimum monitoring standards throughout and for at least 30 minutes after infusion