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In vivo pharmacokinetics, conducted in Sprague-Dawley rats, showed sustained PX plasma levels over two weeks, with a maximum plasma concentration of 19.06 4.73 ng/mL observed at 48 0.25 h

Importantly, the co-existence of abnormal amyloid and Tau protein aggregation in AD could explain the different results in clinical settings

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Under normal conditions, NRF2 is bound in the cytoplasm to its inhibitor KEAP1, which targets it for degradation

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