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doi: 10.1186/1472-6882-9-53 39 FruscalzoA.SalmeriM

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When expressing URA3 heterozygously at the GSH1 locus, a loss of heterozygosity became evident over time under 5-FOA selection, likely attributable to mitotic crossovers

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Moreover, each cancer is likely to be unique in its genetic landscape, and therefore mutational drivers important for invasion could vary significantly from tumour to tumour