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Interestingly, when screening the conditioned media for protein secretion levels against healthy controls, only a significant decrease in IL-8 was detected (Strohmeier et al., 2022)

The mean value of the I response to the target HEK-BFP was 8%, while the I response to the control HEK was lower than 2%, proving the good selectivity

Billon 2023 (ACS Chemical Biology) Preclinical in vivo, 15-28 days, C57BL/6J mice (n = 8-10 per group)

doi: 10.1016/0146-5724(80)90190-9

Compared to precancerous polyps and normal tissues, the demethylation of the NRF2 promoter is significantly increased in tumor tissues, leading to NRF2 overexpression and promoting tumor progression

However, c-MET based immunotherapies has to be till explored in HNSCC to explore its treatment efficacy against HNSCC tumor growth