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In healthy cells and tissues, more than 90% of the total glutathione pool is in the reduced form (GSH) and less than 10% exists in the oxidized form (GSSG)

doi: 10.18632/oncotarget.17986 125 LeekRDLewisCEWhitehouseRGreenallMClarkeJHarrisAL

NSBSO showed GSH-dependent cytotoxicity and depletion of intracellular GSH

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AMPK-related protein kinase 5 (ARK5) is a kinase that has the ability to enable p53 binding activity and regulates the activity of protein phosphatase 1 (PP1) [116, 117]
