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Pain reduction, improved range of motion, better functional capacity, and faster recovery from activity all indicate response

Obeng S, Wilkerson JL, Len F, Reeves ME, Restrepo LF, Gamez-Jimenez LR, et al

Le Maitre CL, Freemont AJ, Hoyland JA

While specific downregulation kinetics for Dihexa haven't been thoroughly characterized in published literature, research on HGF and c-Met signaling in other contexts suggests receptor density begins declining within 2448 hours of sustained agonist exposure, with maximum downregulation occurring around 72 hours

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