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The mechanisms underlying drug resistance are complex, and can include DNA damage repair, genetic mutation, changes in signaling pathways, abnormal transmembrane transport, immune escape, epithelial-mesenchymal transition, changes in the tumor microenvironment (TME), epigenetic changes, autophagy, and cell cycle disorders [6, 12,13,14]

"Conjugated Linoleic Acids impact on fat loss and lean mass." The Journal of Nutrition, 2004

[DOI] [PMC free article] [PubMed] 122.Adams RJ, Cohen DW, Gupte S, Johnson JD, Wallick ET, Wang T, et al

For example, cholesterol-free LNPs containing pH-sensitive cationic lipids, egg sphingomyelin, and PEG-lipid demonstrate instability in blood, resulting in premature siRNA release [141]