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Arancibia S, Lecomte A, Silhol M, Aliaga E, Tapia-Arancibia L (2007) In vivo brain-derived neurotrophic factor release and tyrosine kinase B receptor expression in the supraoptic nucleus after osmotic stress stimulus in rats

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Mechanistic studies revealed that the expression of iron regulatory protein 2 (IRP2), a key regulator of iron homeostasis, is downregulated in age-related cataracts, leading to abnormally elevated free iron levels in the lens ( Furthermore, research has found that the aging process in the lens is accompanied by a decline in autophagic function ( The findings from studies on ferroptosis in age-related cataracts provide valuable insights into the potential role of ferroptosis in radiation-induced cataracts, as both types share common pathogenic factors such as oxidative stress and lipid peroxidation