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10.1038/s41392-022-01229-y 28 ChenP.ChenZ.HouW.YuL

Moreover, oxidatively generated base damage are also associated with increased risk of neurodegenerative diseases (Chen et al

Notably, the inherent susceptibility of pancreatic -cells to ferroptosis provides a mechanistic basis for DM progression, while hyperglycemia reciprocally promotes systemic iron accumulation, thereby establishing a self-reinforcing cycle

Hepatic tissue homogenates were used to detect oxidative stress markers, including malondialdehyde (MDA) and reduced glutathione (GSH)

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Increased iron levels in macrophages also lead to ROS-mediated damage to intracellular systems [14]