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Oxidation of methionine is shown to inhibit the phosphorylation of adjacent Ser/Thr/Tyr sites in proteins

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The benefits of NAC supplementation for RP are two-fold, as NAC not only feeds into GSH biosynthesis pathways following de-acetylation to cysteine but is also able to directly neutralize ROS through its free thiol

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The analysis identified 21 deleterious variants across 12 genes ( PLIN1 , LIPE , ALDH18A1 , PPARG , GHR , INSR , RYR1 , NPC1 , POMC , NR0B2 , GCKR , and PPARA ) in 17 patients [13]