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A subset of clinical research has also demonstrated that adding B12 (and other B-vitamins) to existing antidepressant regimens can improve response rates compared to antidepressants alone, particularly when baseline B12 was suboptimal

Unlike with tablets, these studies identified that there is a very small risk of treatment failure with injectable treatment even when injections are consistently taken on time

In normal physiology it participates in hepatic fat processing and methylation reactions, and it contributes to the livers handling of triglycerides and cholesterol

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