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As expected, the microbial metabolite 5-(3,4-dihydroxyphenyl)--valerolactone appeared later in plasma after 6 h

While enkephalins are present free in plasma only at 3060 pM or 60 ng/L [109], their functional concentration in neuronal synaptosomes has been measured to be approximately 2 M [110] and the intrasynaptic concentration of other neurotransmitters has been calculated to range from a minimum of 2 M to a maximum of 1.5 mM [111,112,113]