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Melanotan-1 (afamelanotide/Scenesse) is the only EMA-approved treatment for EPP, with Phase 3 RCT data showing increased pain-free sun exposure and improved quality of life

Consistent with this model, studies in yeast have shown that HSF1 overexpression enhances ER proteostasis by promoting ERAD 32 , and that the HSR facilitates the removal of damaged ER proteins 15,17
2014;2014:e319215

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[PubMed: 9130995] Redlich GC, Montgomery KD, Allgood GA, et al.: Plexiform fibrohistiocytic tumor with a clonal cytogenetic anomaly