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The Folate Receptor Alpha (FR) is part of a mechanism that actively transports folate into several body organs including the fetus and the brain

More rare are agitation, anxiety surges, or insomnia if dosed too high or late in the day

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This localized discomfort is often a temporary and mild side effect, but occasionally the cause can create a more threatening effect

My personal feeling is that herbal and other alternative/complementary approaches may well ultimately prove to improve inflammation in gout, but that lowering uric (with FDA-approved medications such as allopurinol) is the key to success in gout management