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Crucially, TP53BP1 can promote NHEJ and reduce BRCA1-mediated HRR by restricting DSB resection and antagonizing BRCA2/RAD51 loading in BRCA1-deficient cells [72]
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This fundamental characteristic makes a true vitamin B12 overdose exceptionally rare in clinical practice
One study showed that combining benzoyl peroxide with tretinoin under light exposure cut tretinoin potency by up to 80% within 24 hours
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