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Phase I study of a systemically delivered p53 nanoparticle in advanced solid tumors

Composition GHK-Cu: 50 mg KPV: 10 mg BPC-157: 10 mg TB-500 (Thymosin Beta 4): 10 mg Appearance: lyophilized powder in a sealed research vial Research Focus (non-clinical) Combined evaluation of copper peptide, KPV tripeptide, BPC-157, and TB-500 in in-vitro or ex-vivo assay systems Assay development, including chromatographic separation of four co-formulated peptides Stability characterization of a four-analyte lyophilized blend under laboratory storage conditions Method documentation for HPLC/LC-MS identity and purity assessments Documentation Lot-specific COA available Batch and lot traceability Important Notice For research use only Not for human consumption Not intended to diagnose, treat, cure, or prevent any disease Quality & Manufacturing Lot-specific COA Lyophilized for transit stability

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10.1016/j.biopha.2018.11.103 18 DuryeeM

Overexpression of Nrf1 and Nrf2 restored the rat GCLC promoter activity and response to TBH in F1 and F2 cells, respectively

The cGMP that is produced via NO activation of soluble guanylate cyclase (sGC) in this tissue is degraded by a specific cyclic nucleotide phosphodiesterase (PDE) identified as PDE5A