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Adipose tissue is a major site of peripheral aromatization, where the aromatase enzyme converts adrenal androgens into estrone, leading to higher circulating estrogen levels in obese individuals

Endocrine-Related Cancer (2019) 26:497510

However, it is not inconceivable that even low concentrations might be enough to prevent the return of GABA/benzodiazepine receptors in the brain to their pre-benzodiazepine state

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Br J Anaesth 123(1):e38e49
