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doi: 10.3390/ijms21010300 35 FaasMMDe VosP

This review highlights the dual role of HIF- 1 in CCH-induced VaD

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Successful clinical translation demands a thorough evaluation of biosafety, alongside a detailed investigation of absorption, distribution, metabolism, and excretion (ADME) properties

Mechanistically, it activates autophagy, thereby reducing oxidative stress and inflammationcritical contributors to the pathogenesis of aging and chronic diseasesas well as hormonal changes, including elevated growth hormone levels and reduced insulin levels, which contribute to maintaining metabolic homeostasis

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