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Specifically, we will describe the paradigm change involving the role of bifunctional penicillin-binding proteins (aPBPs) and SEDS/bPBP pairs, and discuss in detail recent studies of RodA/PBP2 and FtsW/PBP3, the SEDS/bPBP pairs that drive PG synthesis in the elongasome and divisome, respectively

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However, this method suffers from a disadvantage associated with a difficulty of application thereof to a practical process due to a high cost of (S)-3-hydroxy-gamma-butyrolactone as the starting material

But the resulting daughter spheres of course have a combined volume smaller than the initial volume