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This is supported by findings that albuminuria develops concurrently with cerebral dysfunction ( Under the conditions of DKD, renal dysfunction leads to an increase in the concentration of nitric oxide inhibitors, disrupting the integrity of the BBB, which in turn contributes to cerebral vascular endothelium injury and cognitive impairment (95)

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Nitric oxide is a critical signaling molecule involved in vasodilation, blood flow regulation, immune function, and tissue repair

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PubMed 18644225 Pickart L., Margolina A