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Dec 1 2013;141(3):2170-2176

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Endogenous biosynthesis Humans can synthesize L-carnitine from the amino acids lysine and methionine in a multi-step process occurring across several cell compartments (cytosol, lysosomes, and mitochondria) (reviewed in 6)

We investigated the influence of different doses (0.1, 1.0, and 2.0 g /kg/day) and time intervals (1, 14, or 28 days) of oral l-carnitine supplementation upon plasma and muscle l-carnitine concentration, as well as upon some aspects of lipid metabolism in rats (submitted data)